HIV infection presenting as bone marrow cryptococcosis | Zendy

Arpana Dharwadkar | Zendy; Shruti Vimal | Zendy; Archana Buch | Zendy; NK Panicker | Zendy

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HIV infection presenting as bone marrow cryptococcosis

Author(s) -

Arpana Dharwadkar,

Shruti Vimal,

Archana Buch,

NK Panicker

Publication year - 2014

Publication title -

advanced biomedical research

Language(s) - English

Resource type - Journals

ISSN - 2277-9175

DOI - 10.4103/2277-9175.135161

Subject(s) - medicine , cryptococcosis , human immunodeficiency virus (hiv) , bone marrow , pathology , immunology , cryptococcus neoformans , opportunistic infection , viral disease , biology , microbiology and biotechnology

Disseminated cryptococcal infection is an uncommon initial manifestation in immunocompromised patients. We report a rare case of a 40-year-old female presenting with fever and burning epigastrium. Peripheral blood film revealed a leukoerythroblastic picture with thrombocytopenia. Bone marrow aspiration showed granulomas along with cryptococcal yeast forms. The ELISA test for detection of human immunodeficiency virus (HIV) antigen was positive. Disseminated cryptococcosis can develop as the first manifestation of HIV infection in previously healthy individuals and granulomas in such bone marrow aspiration smears are a valuable clue to an underlying opportunistic infection

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