Open AccessAn insight into genetics of non-syndromic cleft palate
Author(s) -
Nayereh Nouri,
Padideh Karimi,
Mansoor Salehi,
Mehrdad Memarzadeh,
Hamid Ganji,
Maryam Sedghi
Publication year - 2013
Publication title -
advanced biomedical research
Language(s) - English
Resource type - Journals
ISSN - 2277-9175
DOI - 10.4103/2277-9175.107969
Subject(s) - proband , medicine , sister , inheritance (genetic algorithm) , autosomal recessive inheritance , genetics , multifactorial inheritance , pediatrics , dentistry , biology , mutation , genotype , sociology , gene , anthropology , single nucleotide polymorphism
Our proband is a 29-year-old man, who is affected with soft cleft palate and hypernasality. A study of about six generations of this family pedigree shows that cleft palate has repeatedly occurred in males, with probably a X-linked recessive pattern of inheritance. Interestingly, the sister of the proband is affected with hypernasality and she has an affected son. This is the first report of X-linked inheritance pattern of cleft palate in Iran