Open AccessMyoepithelioma of parotid: A case report and review of literature
Author(s) -
Akhil Kapoor,
Prakash Singh Rajput,
Puneet Kumar Bagri,
Surender Beniwal,
Vanita Kumar,
Harish Kumar
Publication year - 2014
Publication title -
journal of oral research and review
Language(s) - English
Resource type - Journals
eISSN - 2394-2541
pISSN - 2249-4987
DOI - 10.4103/2249-4987.152910
Subject(s) - cytokeratin , vimentin , immunohistochemistry , pathology , calponin , myoepithelioma , myoepithelial cell , carcinoembryonic antigen , salivary gland , parotid gland , medicine , anatomy , cancer
Myoepithelioma (ME) is a rarely encountered tumor of salivary gland accounting for about 1% of all salivary gland tumors. Though they were first identified long back, still their histopathologic features and immunohistochemistry (IHC) profile are not well characterized and there is no definitive criterion for this tumor with complex and varied features remaining a major barrier. We present a case of parotid enlargement in an 18-year-old girl in whom the IHC studies of superficial parotidectomy specimen revealed positive staining for Cytokeratin 5/6, HMW CK, Smooth muscle actin (SMA), S100, calponin, vimentin, and p63. CD45, EMA, CK7, carcinoembryonic antigen (CEA), BerEP4, GCDFP-15, and Glial fibrillary acidic protein (GFAP)-stained negative. With these IHC findings, the diagnosis of ME of parotid was established. This report highlights the importance of IHC studies along with a brief review of the literature