Open AccessStool calprotectin in necrotizing enterocolitis
Author(s) -
Ehab Am Albanna,
Hanan Samir Ahmed,
Hanan Awad
Publication year - 2014
Publication title -
journal of clinical neonatology/journal of clinical neonatology
Language(s) - English
Resource type - Journals
eISSN - 1658-6093
pISSN - 2249-4847
DOI - 10.4103/2249-4847.128721
Subject(s) - calprotectin , necrotizing enterocolitis , medicine , feces , enterocolitis , gastroenterology , immunology , microbiology and biotechnology , biology , disease , inflammatory bowel disease
Calprotectin is a 36 kDa protein present in the cytoplasm of the neutrophil has antimicrobial and apoptosis inducing activities. In vitro studies have shown that calprotectin inhibits the growth of various microorganisms. Necrotizing enterocolitis (NEC) remains one of the leading causes of morbidity and mortality in neonatal intensive care units (NICU), affecting up to 5% of premature infants. Fecal calprotectin is resistant to degradation and has been proposed as a useful marker of gastrointestinal inflammation.