Open AccessPseudohypoaldosteronism type 1: A rare cause of severe dyselectrolytemia and cardiovascular collapse in neonates
Author(s) -
Namasivayam Saravanapandian,
Sarah Paul,
John Matthai
Publication year - 2012
Publication title -
journal of clinical neonatology/journal of clinical neonatology
Language(s) - English
Resource type - Journals
eISSN - 1658-6093
pISSN - 2249-4847
DOI - 10.4103/2249-4847.106007
Subject(s) - hyperkalemia , medicine , pseudohypoaldosteronism , congenital adrenal hyperplasia , peritoneal dialysis , intensive care medicine
Severe hyperkalemia is a medical emergency and occurs due to a variety of underlying illnesses. We present a 7 day old neonate who presented with life threatening hyperkalemia due to pseudohypoaldosteronism type 1 (PHA1). The clinical picture resembled congenital adrenal hyperplasia (CAH). Very aggressive management including peritoneal dialysis was required to control hyperkalemia. It is important to differentiate PHA1 from CAH since the former does not respond to corticosteroid therapy and may require peritoneal dialysis for control of hyperkalemia. A discussion on the types, clinical course, and management of pseudohypoaldosteronism type 1 is presented.