Open AccessThermodynamics of dissolution and infrared-spectroscopy of solid dispersions of phenacetin
Author(s) -
Alexander V. Gerasimov,
Mikhail A. Varfolomeev,
Марат А. Зиганшин,
Valery V. Gorbatchuk,
Ilnaz T. Rakipov,
Alexander E. Klimovitskii,
Liana S. Usmanova
Publication year - 2016
Publication title -
journal of advanced pharmaceutical technology and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 33
eISSN - 2231-4040
pISSN - 0976-2094
DOI - 10.4103/2231-4040.169874
Subject(s) - phenacetin , dissolution , infrared spectroscopy , chemistry , spectroscopy , infrared , thermodynamics , chromatography , organic chemistry , physics , quantum mechanics , optics
In this work enthalpies of dissolution in water of polyethylene glycols (PEGs) having an average molecular weight of 1000 and 1400, Pluronic-F127, phenacetin as well as the composites prepared from them were measured using solution calorimetry at 298.15 K. Intermolecular interaction energies of polymer-phenacetin were calculated on the basis of an additive scheme. It was shown that for mixtures with high content of polymer (>90 wt%) Pluronic-F127 has the highest solubilizing effect, while for mixtures with (4-6):1 polymer: phenacetin ratio the best solubilizing agent is PEG-1400. Infrared-spectra showed a decrease of the number of self-associated molecules of phenacetin with increasing of polymer content in the composites. The obtained results enabled us to identify the features of intermolecular interactions of polymers with a model hydrophobic drug and may be used for optimizing the conditions for preparing solid dispersions based on hydrophilic polymers.