Open AccessCiprofloxacin monoolein water gels as implants for the treatment of chronic osteomyelitis: In vitro characterization
Author(s) -
Bavouma Charles Sombié,
Josias Gérard Yameogo,
Rasmané Semde,
Viviane Henschel,
Karim Amighi,
Jonathan Goole
Publication year - 2014
Publication title -
journal of advanced pharmaceutical technology and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 33
eISSN - 2231-4040
pISSN - 0976-2094
DOI - 10.4103/2231-4040.143029
Subject(s) - ciprofloxacin hydrochloride , ciprofloxacin , thermogravimetric analysis , differential scanning calorimetry , gentamicin , chemistry , in vitro , chromatography , nuclear chemistry , in vivo , materials science , antibiotics , organic chemistry , biochemistry , microbiology and biotechnology , physics , biology , thermodynamics
This work investigated the possibility of using the biodegradable gentamicin-monoolein-water gels as models, in order to obtain a similar sustained release of ciprofloxacin hydrochloride. Four gels containing antibiotics were prepared and were examined with regard to their physicochemical properties and in vitro drug release characteristics. Ciprofloxacin, unlike gentamicin, which was dissolved in the matrix, was in dispersed form. However, despite its insolubility, microscopic observation, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and X-ray diffraction showed that the developed gel was in the cubic liquid crystalline structure and have maintained their ability to progressively release ciprofloxacin. ciprofloxacin-monoolein-water (5:80:15% w/w), which released in vitro approximately 85% of ciprofloxacin after 16 days could possibly be considered as an alternative to a gentamicin-monoolein-water gel for the treatment of chronic osteomyelitis.