Open AccessDevelopment of starch-gelatin complex microspheres as sustained release delivery system
Author(s) -
Vedha Hari B Narayanan,
T Praneetha,
T. Prathyusha,
K Mounika,
D. Ramya Devi
Publication year - 2012
Publication title -
journal of advanced pharmaceutical technology and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 33
eISSN - 2231-4040
pISSN - 0976-2094
DOI - 10.4103/2231-4040.101015
Subject(s) - gelatin , starch , particle size , fourier transform infrared spectroscopy , scanning electron microscope , materials science , particle (ecology) , chemical engineering , drug delivery , modified starch , chemistry , food science , nanotechnology , composite material , organic chemistry , oceanography , engineering , geology
The starch was isolated from jackfruit seeds and evaluated for its preformulation properties, like tapped density, bulk density, and particle size. The fourier transform infrared (FTIR) analysis was done and compared with that of the commercially available starch which confirmed the properties. Using the various concentrations of jackfruit seed starch, the microspheres were prepared, combining with gelatin by ionotropic gelation technique. The developed microspheres were subjected to analysis of particle size, drug content, entrapment efficiency, and percentage yield. The spectral analysis confirmed the presence of drug and absence of interactions. Scanning electron microscope image showed that the particles were in spherical shape with a rough surface. The in vitro drug release in water for 12 hours proved to be in the range of 89 to 100%. The various kinetic models were applied using release data to confirm the mechanism of drug. It was concluded that the jackfruit starch-gelatin microspheres gave satisfactory results and met pharmacopieal limits.