Open AccessVisceral adipose tissue influences on coronary artery calcification at young and middle-age groups using computed tomography angiography
Author(s) -
RamiM Abazid,
M. Obadah Kattea,
Sawsan Sayed,
Hanaa Saqqah,
Mohammed Qintar,
OsamaA Smettei
Publication year - 2015
Publication title -
avicenna journal of medicine
Language(s) - English
Resource type - Journals
eISSN - 2249-4464
pISSN - 2231-0770
DOI - 10.4103/2231-0770.160242
Subject(s) - medicine , multislice computed tomography , adipose tissue , cardiology , coronary artery disease , calcification , computed tomography angiography , coronary calcium score , univariate analysis , confidence interval , subclinical infection , hazard ratio , agatston score , calcinosis , computed tomography , radiology , angiography , coronary artery calcium , multivariate analysis
Purpose: The purpose of the study was to evaluate the impact of excessive visceral adipose tissue (VAT) on subclinical coronary atherosclerosis and coronary artery calcifications (CAC) in young and middle-age groups using multislice computed tomography. Methods: This study is a single center, cross-sectional study. Eligible patients (n = 159), who under the age of 61 years, with chest pain and mild to moderate probability to have coronary artery disease (CAD) were enrolled. Coronary calcium score and epicardial adipose tissue (EAT) were measured at the level of the left main coronary artery while VAT was measured at the level of the iliac crest. Results: The average age was (48 ± 8 years). The mean VAT was (38 ± 21 cm 2 ) with no significant difference between men and women (38 ± 22 vs. 37 ± 19 P = 0.8) respectively. Student′s t-test analysis showed significantly higher VAT in patients with detectable CAC than patients with no CAC (48 ± 24 vs. 33 ± 18 P = 0.00002), respectively. Univariate regression analysis showed that VAT and EAT, are strong predictor for CAC (hazard ratio [HR] 1.034, 95% confidence interval [CI: 1.016-1.052]. P <0.001 and [HR] 1.344, 95% CI: [1.129-1.601] P = 0.001), respectively. Conclusion: Excessive VAT is significantly associated with positive CAC. VAT can strongly predict subclinical CAD in individuals at young and middle-age groups.