Open AccessNanocarrier-based hydrogel of betamethasone dipropionate and salicylic acid for treatment of psoriasis
Author(s) -
Sanjula Baboota,
Sarfaraz Alam,
Shrestha Sharma,
Jasjeet Kaur Sahni,
Anil Kumar,
Javed Ali
Publication year - 2011
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.85963
Subject(s) - isopropyl myristate , microemulsion , permeation , chemistry , salicylic acid , oleic acid , chromatography , nanocarriers , pulmonary surfactant , betamethasone dipropionate , drug delivery , materials science , psoriasis , medicine , dermatology , membrane , organic chemistry , biochemistry
Betamethasone dipropionate (BD) has anti-inflammatory, immunomodulatory, and antiproliferative activity. The aim of the current work was to test the hypothesis that the addition of corticosteroid such as BD and a keratolytic agent such as salicylic acid in nanocarrier based microemulsions formulation would result in enhancement and sustaining of corticosteroid delivery rate leading to better anti-psoriatic activity. Clinical use of BD is restricted to some extent due to its poor permeability across the skin. So to increase its permeation across the skin, microemulsion-based gel formulations were prepared and characterised.