Open AccessMucoadhesive buccal films of glibenclamide: Development and evaluation
Author(s) -
Y. Indira Muzib,
Karuna Kumari
Publication year - 2011
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.76728
Subject(s) - buccal administration , glibenclamide , folding endurance , swelling , materials science , ethyl cellulose , ex vivo , chromatography , permeation , chemistry , nuclear chemistry , pharmacology , in vitro , membrane , medicine , composite material , biochemistry , polymer , diabetes mellitus , endocrinology
Glibenclamide is an oral hypoglycemic drug completely metabolized in the liver, the principal metabolite being very weakly active, buccal delivery may be useful for the treatment of diabetes more effectively. The aim of the present study was to design formulations and systematically evaluate in vitro and ex vivo performances of buccal films of glibenclamide so that the required therapeutic plasma concentrations can possibly be achieved more rapidly using the different grades of hydroxypropyl methyl cellulose (HPMC) as the base matrix.