Open AccessPreparation and characterization of gatifloxacin-loaded sodium alginate hydrogel membranes supplemented with hydroxypropyl methylcellulose and hydroxypropyl cellulose polymers for wound dressing
Author(s) -
D. Prabu,
Amin F. Majdalawieh,
Imad A. AbuYousef,
Kadambari Inbasekaran,
Tharani Balasubramaniam,
Narayanan Nallaperumal,
Conjeevaram J. Gunasekar
Publication year - 2016
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.177810
Subject(s) - membrane , glutaraldehyde , swelling , chemical engineering , hydroxypropyl cellulose , materials science , polymer , ultimate tensile strength , self healing hydrogels , gelatin , polymer chemistry , chitosan , differential scanning calorimetry , bacterial cellulose , gatifloxacin , kinetics , chemistry , cellulose , chromatography , organic chemistry , composite material , biochemistry , physics , engineering , thermodynamics , antibiotics , quantum mechanics , ciprofloxacin
The aim of this study is to evaluate gatifloxacin-loaded sodium alginate hydrogel membranes, supplemented with glycerol (a plasticizer), glutaraldehyde (a cross-linking agent), and hydroxypropyl methylcellulose (HPMC) or hydroxypropyl cellulose (HPC) polymers, as potential wound dressing materials based on their physicochemical properties and the sustain-release phenomenon.