Open AccessFormulation, characterization and evaluation of the effect of polymer concentration on the release behavior of insulin-loaded Eudragit®-entrapped mucoadhesive microspheres
Author(s) -
Franklin Chimaobi Kenechukwu,
Mumuni A. Momoh
Publication year - 2016
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.177806
Subject(s) - coacervate , magnesium stearate , polymer , materials science , microsphere , dosage form , chromatography , dissolution , magnesium , nuclear chemistry , chemistry , chemical engineering , organic chemistry , composite material , engineering , metallurgy
The aim of this study was to use Eudragit(®) RL 100 (pH-independent polymer) and magnesium stearate (a hydrophobic droplet stabilizer) in combination to improve the controlled release effect of insulin-loaded Eudragit(®) entrapped microspheres prepared by the emulsification-coacervation technique.