Open AccessDevelopment and evaluation of solid dispersion of spironolactone using fusion method
Author(s) -
_ Shamsuddin,
Mohammad Fazil,
S. H. Ansari,
Javed Ali
Publication year - 2016
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.176490
Subject(s) - spironolactone , fusion , materials science , dispersion (optics) , computer science , medicine , optics , physics , aldosterone , philosophy , linguistics
Solubility and dissolution of a poor water-soluble drug are the two major barriers for formulation scientists in development of drug delivery. Many of the potent drugs do not show the therapeutic effects due to solubility issues but may show toxicity issues when used in high doses. Solid dispersion (SD) technology is an excellent tool for enhancing the solubility and dissolution and hence related bioavailability.