Open AccessFormulation and characterization of hydrochlorothiazide solid lipid microparticles based on lipid matrices of Irvingia fat
Author(s) -
Chukwuma O. Agubata,
Salome Amarachi Chime,
Franklin Chimaobi Kenechukwu,
Ifeanyi T. Nzekwe,
Godswill C. Onunkwo
Publication year - 2014
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.143120
Subject(s) - hydrochlorothiazide , chromatography , bioavailability , particle size , chemistry , materials science , food science , pharmacology , biology , blood pressure , endocrinology
The purpose of this study was to improve the solubilization, bioavailability, and permeability of hydrochlorothiazide (HCTZ) by the formulation and characterization of HCTZ solid lipid microparticles (SLMs) based on fat derived from Irvingia gabonensis var. excelsa (Irvingia wombolu) and Phospholipon(®)90G (P90G).