Open AccessInvestigation of moxifloxacin loaded chitosan-dextran nanoparticles for topical instillation into eye: In-vitro and ex-vivo evaluation
Author(s) -
Raad A Kaskoos
Publication year - 2014
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.143114
Subject(s) - chitosan , moxifloxacin , zeta potential , permeation , dispersity , particle size , chemistry , chromatography , box–behnken design , in vitro , in vivo , materials science , nanoparticle , biomedical engineering , nuclear chemistry , nanotechnology , membrane , response surface methodology , medicine , antibiotics , polymer chemistry , biochemistry , microbiology and biotechnology , biology
Management of ocular surface disease by conventional formulation is limited by poor residence of drug at cul-de-sac of eye. To overcome this limitation, prolonged released mucoadhesive chitosan (CS)-dextran sulfate (DS) nanoparticles (NPs) were investigated for the prolonged topical ophthalmic delivery of moxifloxacin (Mox).