Open AccessTargeting silymarin for improved hepatoprotective activity through chitosan nanoparticles
Author(s) -
Swati Gupta,
Shailendra Kumar Singh,
Priti Girotra
Publication year - 2014
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.143113
Subject(s) - silybum marianum , carbon tetrachloride , milk thistle , pharmacology , chitosan , in vitro , chemistry , drug , silibinin , hepatoprotection , traditional medicine , drug delivery , medicine , biochemistry , organic chemistry , glutathione , enzyme
Silymarin is one of the best known hepatoprotective drugs, which is obtained from the seeds of Silybum marianum L., Family: Asteraceae or Compositae. The plant has traditionally been used for centuries as a natural remedy for liver and biliary tract diseases. The aim of the present investigation was to enhance the hepatoprotective activity of silymarin by incorporating it in chitosan (Ch) nanoparticles (NPs) for passive targeted delivery, thereby prolonging its retention time.