Open AccessEthyl cellulose and hydroxypropyl methyl cellulose buoyant microspheres of metoprolol succinate: Influence of pH modifiers
Author(s) -
Neha S. Raut,
Sachin Somvanshi,
Amol Baburao Jumde,
Harsha M Khandelwal,
Milind J. Umekar,
Nandkishor R. Kotagale
Publication year - 2013
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.119235
Subject(s) - ethyl cellulose , methyl cellulose , chemistry , tartaric acid , nuclear chemistry , citric acid , hydroxypropyl cellulose , chromatography , polymer , cellulose , dissolution , organic chemistry
Incorporation of pH modifier has been the usual strategy employed to enhance the dissolution of weakly basic drug from floating microspheres. Microspheres prepared using a combination of both ethyl cellulose (EC) and hydroxypropyl methylcellulose (HPMC) which shows highest release were utilize to investigate the effect of fumaric acid (FA), citric acid (CA), ascorbic acid (AA) and tartaric acid (TA) (all 5-20% w/w) incorporation on metoprolol succinate (MS) release.