Open AccessDevelopment and evaluation of chitosan based oral controlled matrix tablets of losartan potassium
Author(s) -
Tallapaneni Vishnuvardhan Rao,
GB Kiran Kumar,
Mohammed Gulzar Ahmed,
Vedamurthy Joshi
Publication year - 2012
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.104399
Subject(s) - polymer , granulation , dissolution , angle of repose , chitosan , materials science , chemical engineering , chromatography , chemistry , controlled release , solubility , nuclear chemistry , organic chemistry , composite material , nanotechnology , engineering
The novelty of the present study was to control the release profile of matrix tablets of losartan potassium prepared by using different concentrations of chitosan and trisodium citrate as cross-linking agent with combination of various release retardant polymers.