Open AccessSolid-state characterization of lacidipine/PVP K29/32solid dispersion primed by solvent co-evaporation
Author(s) -
Amit Mukharya,
Shivang Chaudhary,
Niyaz Mansuri,
A. K. Misra
Publication year - 2012
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.100048
Subject(s) - fourier transform infrared spectroscopy , crystallinity , polyvinylpyrrolidone , dissolution , differential scanning calorimetry , materials science , solubility , hydrogen bond , solvent , nuclear chemistry , analytical chemistry (journal) , chemical engineering , chemistry , polymer chemistry , organic chemistry , molecule , physics , engineering , composite material , thermodynamics
Lacidipine (LCDP) is a 1,4-dihydropyridine derivative categorized as an anti-hypertensive Ca2+ channel blocker having very low solubility, and thus very low oral bioavailability, which presents a challenge to the formulation scientists. Homogeneous distribution of poorly water-soluble drugs like LCDP in polyvinylpyrrolidone (PVP), a hydrophilic carrier, is definitely a suitable way to improve the bioavailability of such drugs.