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Lacidipine (LCDP) is a 1,4-dihydropyridine derivative categorized as an anti-hypertensive Ca2+ channel blocker having very low solubility, and thus very low oral bioavailability, which presents a challenge to the formulation scientists. Homogeneous distribution of poorly water-soluble drugs like LCDP in polyvinylpyrrolidone (PVP), a hydrophilic carrier, is definitely a suitable way to improve the bioavailability of such drugs.

Solid-state characterization of lacidipine/PVP K29/32solid dispersion primed by solvent co-evaporation

Solid-state characterization of lacidipine/PVP K_29/32solid dispersion primed by solvent co-evaporation