Open AccessOxidative stress in hypothyroid patients and the role of antioxidant supplementation
Author(s) -
Sumit Kumar Chakrabarti,
Sujoy Ghosh,
Sandip Banerjee,
Satinath Mukherjee,
Subhankar Chowdhury
Publication year - 2016
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/2230-8210.190555
Subject(s) - medicine , oxidative stress , malondialdehyde , endocrinology , thyroid , autoimmune thyroiditis , context (archaeology) , hormone , placebo , antioxidant , glutathione peroxidase , thyroid peroxidase , thyroiditis , superoxide dismutase , biochemistry , pathology , chemistry , alternative medicine , paleontology , biology
The available data concerning oxidant stress and antioxidant capacity in hypothyroidism are scanty and inconclusive. While some authors suggest that tissues may be protected from oxidant damage because of a hypometabolic state in hypothyroidism, others report increased oxidative stress in hypothyroidism. Selenium acts as a cofactor for the thyroid hormone (TH) deiodinases that activate and then deactivate various THs and their metabolites. Selenium may inhibit thyroid autoimmunity.