Open AccessPlasma free metanephrine, normetanephrine, and 3-methoxytyramine for the diagnosis of pheochromocytoma/paraganglioma
Author(s) -
Pratyush Gupta,
Madan Lal Khurana,
Rajesh Khadgawat,
Chandrasekhar Bal,
Guresh Kumar,
Surendra Sharma,
Nikhil Tandon
Publication year - 2015
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/2230-8210.163183
Subject(s) - metanephrine , normetanephrine , pheochromocytoma , medicine , paraganglioma , multiple endocrine neoplasia , multiple endocrine neoplasia type 2 , metanephrines , endocrinology , neurofibromatosis , gastroenterology , urology , pathology , chemistry , biochemistry , germline mutation , mutation , gene
Pheochromocytomas (PHEO) and paragangliomas (PGL) are derived from paraganglia of the sympathetic and parasympathetic nervous system. Most of the sympathetic PHEO/PGL secrete either catecholamine or their metabolites, metanephrines, whereas parasympathetic PHEO/PGL are nonsecretory. We assessed the utility of plasma free 3-methoxytyramine (3MT), normetanephrine (NM), and metanephrine (MN) for the diagnosis of PHEO/PGL.