Open AccessGrowth hormone - insulin-like growth factor-I axis and bone mineral density in adults with thalassemia major
Author(s) -
Ashraf T. Soliman,
Vincenzo De Sanctis,
Mohamed A Yassin,
Mohamed Abdel-Rahman
Publication year - 2014
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/2230-8210.126525
Subject(s) - medicine , endocrinology , bone mineral , short stature , thalassemia , bone age , n terminal telopeptide , insulin like growth factor , growth factor , osteoporosis , alkaline phosphatase , osteocalcin , biochemistry , chemistry , enzyme , receptor
Bone disease and short stature are frequent clinical features of patients with beta-thalassaemia major. Dysfunction of the GH-IGF-1 axis has been described in many thalassemics children and adolescents with short stature and reduced growth velocity. Assessment of the GH-IGF-1 axis in short adults with TM after attainment of final height may be required to select those who are candidates for replacement therapy and to prevent the development of bone disease. The aim of our study was to investigate GH secretion in adult thalassemic patients in relation to their bone mineral density (BMD) and serum ferritin concentrations.