Open AccessPersistence of histoplasma in adrenals 7 years after antifungal therapy
Author(s) -
Deepak Kothari,
Shweta Chopra,
Minakshi Bhardwaj,
Ajay K. Ajmani,
Bindu Kulshreshtha
Publication year - 2013
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/2230-8210.111679
Subject(s) - histoplasmosis , medicine , itraconazole , histoplasma , adrenal insufficiency , persistence (discontinuity) , amphotericin b , antifungal , biopsy , histoplasma capsulatum , histology , dermatology , geotechnical engineering , engineering
Adrenal histoplasmosis is an uncommon cause for adrenal insufficiency. The duration of treatment for adrenal histoplasmosis is not clear. Existing treatment regimens advocate antifungals given for periods ranging from 6 months to 2 years. We report here a rare case who showed persistence of histoplasma in adrenal biopsy 7 years after being initially treated with itraconazole for 9 months. This calls for a prolonged therapy with regular review of adrenal morphology and histology in these patients.