Open AccessTranscriptomic analysis of visceral adipose from healthy and diabetic obese subjects
Author(s) -
Sandeep Kumar Mathur,
Priyanka Jain,
Prashant Mathur,
Prakash P Punjabi,
Atima Agarwal,
Abhay Sharma
Publication year - 2013
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/2230-8210.111639
Subject(s) - adipose tissue , transcriptome , inflammation , metabolic syndrome , medicine , endocrinology , diabetes mellitus , obesity , intra abdominal fat , body mass index , downregulation and upregulation , microarray , gene , gene expression , biology , insulin resistance , biochemistry , visceral fat
Understanding the role of visceral fat accumulation in the occurrence and progression of metabolic syndrome is of considerable interest. In order to understand the difference between visceral tissue biology of healthy and unhealthy obese individuals, we have used microarray profiling to compare genome-wide expression differences between visceral adipose tissue biopsies obtained from obese diabetics, and those from age and body mass index (BMI) matched normal glucose tolerance subjects. Whereas genes upregulated in diabetics showed enrichment of natural killer cell mediated cytotoxicity, the downregulated genes showed enrichment of biosynthesis of unsaturated fatty acids. Given the known inhibitory effect of unsaturated fatty acids on inflammation and natural killer cell number or activity, our results suggest that visceral inflammation resulting from decreased levels of unsaturated fatty acids may underlie progression of diabetes in obese individuals.