Open AccessPromise and pitfalls of molecular markers of thyroid nodules
Author(s) -
Swati Jadhav,
Anurag Lila,
Tushar Bandgar,
Nalini Shah
Publication year - 2012
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/2230-8210.104030
Subject(s) - thyroid nodules , medicine , thyroid , fine needle aspiration , pathology , molecular diagnostics , indeterminate , biopsy , cytology , population , radiology , bioinformatics , biology , mathematics , environmental health , pure mathematics
Thyroid nodules are common in the general population with a prevalence of 5-7% The initial evaluation of thyroid nodules commonly involves thyroid function tests, an ultrasound (USG) and fine needle aspiration biopsy (FNAB). The optimal management of patients with thyroid nodules with indeterminate cytology is plagued by the lack of highly sensitive and specific diagnostic modalities In this article we attempt to review the available literature on the molecular markers which are increasingly being studied for their diagnostic utility in assessing thyroid nodules. The various molecular markers consist of gene mutations, gene re arrangements, RNA based assays and immunohistochemical markers. The molecular markers definitely would help to optimise the management of such patients.