Open AccessSeronegative necrolytic acral erythema: A report of two cases and literature review
Author(s) -
Vishalakshi S Pandit,
Arun C Inamadar,
Aparna Palit
Publication year - 2016
Publication title -
indian dermatology online journal
Language(s) - English
Resource type - Journals
eISSN - 2249-5673
pISSN - 2229-5178
DOI - 10.4103/2229-5178.185464
Subject(s) - medicine , hyperglucagonemia , dermatology , erythema , hepatitis c virus , zinc deficiency (plant disorder) , hepatitis c , acrodermatitis , pathology , virus , immunology , glucagon , micronutrient , alternative medicine , hormone
Necrolytic acral erythema (NAE) is a newly described entity, seen in patients infected with hepatitis C virus. It is characterized by its distinguishing acral distribution, psoriasiform skin eruption and histological features. Its etiopathogenesis is not fully understood though hypo amino academia, hyperglucagonemia and zinc deficiency are considered as probable causes. In 1996, El Darouti and Abu el Ela first described this entity in seven Egyptian patients with hepatitis C virus (HCV). Since then, several small studies and cases have been reported around the world. Nevertheless, it may occur independently without HCV association as a few cases have been reported recently. We report two seronegative cases of NAE, which responded dramatically with oral zinc therapy. This suggests that NAE could be an isolated clinical subset.