Open AccessTreatment of refractory ulcerative necrobiosis lipoidica diabeticorum with oral thalidomide
Author(s) -
Swapnil Shah,
Girish V Kale
Publication year - 2016
Publication title -
indian dermatology online journal
Language(s) - English
Resource type - Journals
eISSN - 2249-5673
pISSN - 2229-5178
DOI - 10.4103/2229-5178.174328
Subject(s) - necrobiosis lipoidica , medicine , thalidomide , refractory (planetary science) , dermatology , treatment modality , surgery , diabetes mellitus , physics , astrobiology , multiple myeloma , endocrinology
Ulcerative necrobiosis lipoidica (NL) in diabetic patients is a rare, painful condition. It is a difficult-to-treat condition, impairing quality of life of patients. Although various drugs have been tried, none of them is consistently effective. Biologics in the form of TNF-alpha inhibitors show promising results in the treatment. But because of their high cost we chose thalidomide, which also has TNF-alpha inhibiting properties to successfully treat a long-standing case of ulcerative NL, which was refractory to various treatment modalities.