Open AccessPseudoxanthoma elasticum and nephrocalcinosis: Incidental finding or an infrequent manifestation?
Author(s) -
Tirthankar Gayen,
Anupam Das,
Sudipta Roy,
Subhas C. Biswas,
Kaushik Shome,
Satyendra Nath Chowdhury
Publication year - 2014
Publication title -
indian dermatology online journal
Language(s) - English
Resource type - Journals
eISSN - 2249-5673
pISSN - 2229-5178
DOI - 10.4103/2229-5178.131094
Subject(s) - pseudoxanthoma elasticum , nephrocalcinosis , medicine , calcification , asymptomatic , pathology , calcinosis , angioid streaks , h&e stain , dermatology , staining , kidney , surgery , visual acuity , choroidal neovascularization
Pseudoxanthoma elasticum (PXE) is an inherited disorder characterized by generalized fragmentation and progressive calcification of elastic tissue. We report two sporadic cases of PXE, both of whom presented with asymptomatic yellowish papules over the flexural sites for cosmetic reasons. Histopathological findings on hematoxylin and eosin and Verhoeff-Van Gieson (VVG) staining were classical of PXE. In addition to this, renal calcification was documented on plain radiography of kidneys, ureters, and bladder (KUB) in both the cases. Paucity of literature describing the association of nephrocalcinosis with PXE prompted the present report.