Open AccessApelin protect against multiple organ injury following hemorrhagic shock and decrease the inflammatory response
Author(s) -
Mona Soliman,
Maha Arafah
Publication year - 2015
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/2229-516x.165377
Subject(s) - apelin , medicine , tumor necrosis factor alpha , hemorrhagic shock , inflammation , in vivo , resuscitation , shock (circulatory) , receptor , blood pressure , cytokine , necrosis , pharmacology , endocrinology , pathology , anesthesia , biology , microbiology and biotechnology
Hemorrhagic shock (HS) result in multiple organ injury and inflammatory response that lead to death. The exact mechanism is not clear. Apelin is an endogenous ligand of orphan G-protein coupled receptor APJ. Apelin has anti-inflammatory effects on the release of inflammatory mediators.