Open AccessPresence of pathogenicity island related and plasmid encoded virulence genes in cytolethal distending toxin producing Escherichia coli isolates from diarrheal cases
Author(s) -
Mana Oloomi,
Maryam Javadi,
Saeid Bouzari
Publication year - 2015
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/2229-516x.165366
Subject(s) - virulence , cytolethal distending toxin , biology , prophage , pathogenicity island , mobile genetic elements , plasmid , microbiology and biotechnology , horizontal gene transfer , shiga toxin , gene , escherichia coli , genetics , toxin , polymerase chain reaction , virology , bacteriophage , genome
Mobile genetic elements such as plasmids, bacteriophages, insertion elements, and genomic islands play a critical role in virulence of bacterial pathogens. These elements transfer horizontally and could play an important role in the evolution and virulence of many pathogens. A broad spectrum of gram-negative bacterial species has been shown to produce a cytolethal distending toxin (CDT). On the other hand, Shiga toxin producing Escherichia coli are the one carry virulence genes such as stx 1 and stx 2 (Shiga toxin) and these genes can be acquired by horizontal gene transfer.