Open AccessThe paradox of recurrent with rare: A rare case of bilateral proptosis and facial palsy in acute myeloid leukemia with recurrent cytogenetic translocation t(8:21)
Author(s) -
Rohit Kapoor,
Jitender Mohan Khunger,
Atul Sharma,
Sandeep Sachdeva
Publication year - 2015
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/2229-516x.149256
Subject(s) - medicine , myeloid leukemia , chromosomal translocation , biopsy , myeloid sarcoma , leukemia , palsy , myeloid , rare disease , pathology , dermatology , disease , biology , biochemistry , alternative medicine , gene
A 13-year-old female child presented with bilateral proptosis and subconjuctival hemorrhage of 2 months duration. Subsequently, the biopsy and peripheral smears confirmed the diagnosis of acute myeloid leukemia (AML). Recurrent cytogenetic translocation t(8:21) in AML associated with extramedullary manifestation; was discovered which is a rare event. Furthermore, myeloperoxidase negative blasts and periodic acid Schiff negative blasts in AML with t(8:21) is a very rare combination to the best of our knowledge.