Open AccessHepatoprotective effects of select water-soluble PARP inhibitors in a carbon tetrachloride model
Author(s) -
James McCluskey,
Dmytro Sava,
Stephen C. Harbison,
Carlos Muro-Cacho,
Johnson T Giffe,
Ping Xu,
Raymond D. Harbison
Publication year - 2011
Publication title -
international journal of critical illness and injury science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.274
H-Index - 12
eISSN - 2231-5004
pISSN - 2229-5151
DOI - 10.4103/2229-5151.84788
Subject(s) - poly adp ribose polymerase , carbon tetrachloride , lipid peroxidation , glutathione , oxidative stress , pharmacology , medicine , hepatocyte , biochemistry , chemistry , enzyme , polymerase , organic chemistry , in vitro
Inhibitors of the nuclear enzyme poly (ADP-ribose) polymerase (PARP-1) have been demonstrated to attenuate pathophysiologic conditions associated with oxidative stress, specifically with carbon tetrachloride (CT)-induced hepatotoxicity.