Hepatoprotective effects of select water-soluble PARP inhibitors in a carbon tetrachloride model | Zendy

RaymondD Harbison | Zendy; JamesD McCluskey | Zendy; Dmytro Sava | Zendy; StephenC Harbison | Zendy; CarlosA Muro-Cacho | Zendy; JohnsonT Giffe | Zendy; Ping Xu | Zendy

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Hepatoprotective effects of select water-soluble PARP inhibitors in a carbon tetrachloride model

Author(s) -

RaymondD Harbison,

JamesD McCluskey,

Dmytro Sava,

StephenC Harbison,

CarlosA Muro-Cacho,

JohnsonT Giffe,

Ping Xu

Publication year - 2011

Publication title -

international journal of critical illness and injury science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.274

H-Index - 12

eISSN - 2231-5004

pISSN - 2229-5151

DOI - 10.4103/2229-5151.84788

Subject(s) - poly adp ribose polymerase , carbon tetrachloride , lipid peroxidation , glutathione , oxidative stress , pharmacology , medicine , hepatocyte , biochemistry , chemistry , enzyme , polymerase , organic chemistry , in vitro

Inhibitors of the nuclear enzyme poly (ADP-ribose) polymerase (PARP-1) have been demonstrated to attenuate pathophysiologic conditions associated with oxidative stress, specifically with carbon tetrachloride (CT)-induced hepatotoxicity.

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