Olanzapine overdose presenting with acute muscle toxicity | Zendy

GentleSunder Shrestha | Zendy; Niraj Kumar Keyal | Zendy; Saurabh Pradhan | Zendy; Ramesh Kumar Maharjan | Zendy; SubhashPrasad Acharya | Zendy; ModaNath Marhatta | Zendy

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Olanzapine overdose presenting with acute muscle toxicity

Author(s) -

GentleSunder Shrestha,

Niraj Kumar Keyal,

Saurabh Pradhan,

Ramesh Kumar Maharjan,

SubhashPrasad Acharya,

ModaNath Marhatta

Publication year - 2017

Publication title -

international journal of critical illness and injury science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.274

H-Index - 12

eISSN - 2231-5004

pISSN - 2229-5151

DOI - 10.4103/2229-5151.201962

Subject(s) - olanzapine , medicine , toxicity , creatine kinase , atypical antipsychotic , rhabdomyolysis , drug overdose , acute toxicity , anesthesia , skeletal muscle , antipsychotic , pharmacology , poison control , emergency medicine , schizophrenia (object oriented programming) , psychiatry

Olanzapine is an atypical antipsychotic drug that is being increasingly used as an intentional overdose. It usually presents with reduced and fluctuating level of consciousness and coma. It may rarely present with muscle toxicity by binding to HT2A receptor in skeletal muscle and increasing its permeability. We report a case of such poisoning which had no obvious symptoms but was brought to emergency due to overdose and was found to have acute muscle toxicity as evidenced by raised creatine phosphokinase (CPK) levels. From this, we also want to emphasize that CPK levels should be checked in all the patient's prescribed olanzapine to look for muscle toxicity.

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