Open AccessOlanzapine overdose presenting with acute muscle toxicity
Author(s) -
Niraj Kumar Keyal,
Gentle Sunder Shrestha,
Saurabh Pradhan,
Ramesh Kumar Maharjan,
Subhash Prasad Acharya,
Moda Nath Marhatta
Publication year - 2017
Publication title -
international journal of critical illness and injury science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.274
H-Index - 12
eISSN - 2231-5004
pISSN - 2229-5151
DOI - 10.4103/2229-5151.201962
Subject(s) - olanzapine , medicine , toxicity , creatine kinase , atypical antipsychotic , rhabdomyolysis , drug overdose , acute toxicity , anesthesia , skeletal muscle , antipsychotic , pharmacology , poison control , emergency medicine , schizophrenia (object oriented programming) , psychiatry
Olanzapine is an atypical antipsychotic drug that is being increasingly used as an intentional overdose. It usually presents with reduced and fluctuating level of consciousness and coma. It may rarely present with muscle toxicity by binding to HT2A receptor in skeletal muscle and increasing its permeability. We report a case of such poisoning which had no obvious symptoms but was brought to emergency due to overdose and was found to have acute muscle toxicity as evidenced by raised creatine phosphokinase (CPK) levels. From this, we also want to emphasize that CPK levels should be checked in all the patient's prescribed olanzapine to look for muscle toxicity.