Open AccessBone marrow hematopoietic stem cells behavior with or without growth factors in trauma hemorrhagic shock
Author(s) -
Manoj Kumar,
Sanjeev Bhoi,
Sujata Mohanty,
Vineet Kumar Kamal,
D. N. Rao,
Pravas Mishra,
Sagar Galwankar
Publication year - 2016
Publication title -
international journal of critical illness and injury science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.274
H-Index - 12
eISSN - 2231-5004
pISSN - 2229-5151
DOI - 10.4103/2229-5151.190654
Subject(s) - medicine , hemorrhagic shock , haematopoiesis , bone marrow , stem cell , shock (circulatory) , pathology , immunology , microbiology and biotechnology , biology
Hemorrhagic shock (HS) is the major leading cause of death after trauma. Up to 50% of early deaths are due to massive hemorrhage. Excessive release of pro-inflammatory cytokine and hypercatecholamine induces hematopoietic progenitor cells (HPCs) apoptosis, leading to multiorgan failure and death. However, still, result remains elusive for hematopoietic stem cells (HSCs) behavior in trauma HS (T/HS).