Open AccessPrior cholecystectomy predisposes to acute pancreatitis in codeine-prescribed patients
Author(s) -
Serdar Türkmen,
Hakan Büyükhatipoğlu,
Ali Süner,
Hacı Gökhan Apucu,
Turgay Ulaş
Publication year - 2015
Publication title -
international journal of critical illness and injury science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.274
H-Index - 12
eISSN - 2231-5004
pISSN - 2229-5151
DOI - 10.4103/2229-5151.158416
Subject(s) - codeine , medicine , pancreatitis , cholecystectomy , acetaminophen , anesthesia , acute pancreatitis , pill , heroin , drug , morphine , pharmacology
In this paper, we report a case of drug-induced pancreatitis just after taking a pain pill including a low-dose combination of acetaminophen and codeine. Codeine-induced pancreatitis has been rarely reported, however, well-established. The proposed mechanism for codeine-induced pancreatitis is by increasing Oddi sphincter pressure. However, the clinically important point is that the codeine-induced pancreatitis is seen almost only in the cholecystectomized patients due to lacking of its reservoir capacity. Codeine is commonly used alone or in combination in pain medicine. Therefore, it is fairly important to question whether a patient underwent cholecystectomy when a physician decides to prescribe codeine-included preparations.