Open AccessAntimalarial drug resistance: An overview
Author(s) -
Hiasindh Ashmi Antony,
Subhash Chandra Parija
Publication year - 2016
Publication title -
tropical parasitology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.418
H-Index - 11
eISSN - 2229-7758
pISSN - 2229-5070
DOI - 10.4103/2229-5070.175081
Subject(s) - malaria , drug , drug resistance , mechanism (biology) , drug action , pharmacology , medicine , intensive care medicine , biology , computational biology , immunology , genetics , philosophy , epistemology
Malaria is a major public health burden throughout the world. Resistance to the antimalarial drugs has increased the mortality and morbidity rate that is achieved so far through the malaria control program. Monitoring the drug resistance to the available antimalarial drugs helps to implement effective drug policy, through the in vivo efficacy studies, in vitro drug susceptibility tests and detection of molecular markers. It is important to understand the mechanism of the antimalarial drugs, as it is one of the key factors in the emergence and spread of drug resistance. This review summarizes the commonly used antimalarial drugs, their mechanism of action and the genetic markers validated so far for the detection of drug-resistant parasites.