Open AccessMicroRNA therapeutics: Discovering novel targets and developing specific therapy
Author(s) -
Ajay Francis Christopher,
Raman Preet Kaur,
Gurpreet Kaur,
Amandeep Kaur,
Avijit Mazumder,
Parveen Bansal
Publication year - 2016
Publication title -
perspectives in clinical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.649
H-Index - 8
eISSN - 2229-5488
pISSN - 2229-3485
DOI - 10.4103/2229-3485.179431
Subject(s) - microrna , computational biology , biology , bioinformatics , non coding rna , disease , mechanism (biology) , gene , medicine , genetics , pathology , philosophy , epistemology
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression in diverse biological process. They act as intracellular mediators that are necessary for various biological processes. MicroRNAs targeting pathways of human disease provide a new and potential powerful candidate for therapeutic intervention against various pathological conditions. Even though, the information about miRNA biology has significantly enriched but we still do not completely understand the mechanism of miRNA gene regulation. Various groups across the globe and pharmaceutical companies are conducting research and developments to explore miRNA based therapy and build a whole new area of miroRNA therapeutics. Consequently, few miRNAs have entered the preclinical and clinical stage and soon might be available in the market for use in humans.