Open AccessAcute lung injury mechanism and therapy induced by paraquat poisoning
Author(s) -
Xianli Liu,
Xiaoran Liu,
Chuan-Zhu Lu
Publication year - 2017
Publication title -
journal of acute disease
Language(s) - English
Resource type - Journals
eISSN - 2589-5516
pISSN - 2221-6189
DOI - 10.4103/2221-6189.221289
Subject(s) - paraquat , medicine , detoxification (alternative medicine) , acute respiratory distress , drug , acute toxicity , pathogenesis , mechanism (biology) , lung , pharmacology , intensive care medicine , toxicology , toxicity , pathology , biology , biochemistry , alternative medicine , philosophy , epistemology
Paraquat (PQ, methyl viologen) was widely used in agricultural production throughout the world in 1962 for its efficient herbicidal activity. PQ was also highly toxic drug. About 5 mL medicine including 20% paraquat was life-threatening that can cause poisoning. In 1966, some people died because of PQ poisoning. Most patients had acute respiratory distress syndrome after 2 wk, and 70% of them died due to the lack of effective detoxification drugs. Thus, it was particularly important to understand the pathogenesis of PQ poisoning and give some effective treatments. This article will review the toxicological mechanism and treatment on PQ poisoning of acute lung injury