Open AccessResearch progress of transfering mitochondria application in nanotubes in treatment of acute lung injury sepsis
Author(s) -
Jin Qian,
Dandan Sun,
Qi-Feng Huang,
Xiaoran Liu
Publication year - 2017
Publication title -
journal of acute disease
Language(s) - English
Resource type - Journals
eISSN - 2589-5516
pISSN - 2221-6189
DOI - 10.4103/2221-6189.221286
Subject(s) - medicine , sepsis , mitochondrion , lung , intensive care medicine , microbiology and biotechnology , surgery , biology
Acute lung injury (ALI) is a common complication of sepsis with characteristics of acute onset, rapid change in the disease and high mortality. Since current clinical treatment can only alleviate the unfavorable condition to a certain extent but cure, we urgently need to find an effective treatment. Most scholars believe that sepsis-induced ALI is associated with extensive mitochondrial damage. In recent years, a widely studied pluripotent stem cell that is mesenchymal stem cell has been proved to alleviate and treat sepsis-induced ALI by transporting mitochondria via nanotubes in a microtubule-dependent manner. Research progress in this field will be reviewed in this study