Open AccessProtective effects of Aristolochia longa and Aquilaria malaccensis against lead induced acute liver injury in rats
Author(s) -
Samir Derouiche,
Khaoula Zeghib,
Safa Gharbi,
Yahia Khelef,
Anouar Feriani
Publication year - 2017
Publication title -
journal of acute disease
Language(s) - English
Resource type - Journals
eISSN - 2589-5516
pISSN - 2221-6189
DOI - 10.4103/2221-6189.219611
Subject(s) - rhizome , curcuma , hepatoprotection , medicine , traditional medicine , oxidative stress , glutathione , pharmacology , toxicology , biology , enzyme , biochemistry
Objective: To investigate the protective effects of Aristolochia longa (A. longa) and Aquilaria\udmalaccensis (A. malaccensis) on acute hepatotoxicity induced by lead in female albino rats.\udMethods: Twenty five (25) apparently healthy female Wistar rats were randomly divided into\udfive groups of five rats in each: control, Pb, Pb + A. longa (Ar), Pb+ A. malaccensis (Aq), and\udPb+ A. longa (Ar) + A. malaccensis (Aq) lead (100 mg/kg b.w.) as Pb (C2H3O2)2 added in their\uddrinking water for 75 days. A. longa (rhizome powder at a dose of 10 g/kg of diet ) and A.\udmalaccensis (heartwood powder at a dose 10 g/kg of diet) were added to the feed during the last\ud15 days of lead exposed in the animals. Results: Obtained results revealed that lead treatment\udcaused a significant increase in serum GOT, GPT and ALP activities and in liver of MDA level\udand CAT activity. In contrast, it led to an decrease in the liver GOT, GPT and GST activities\udand in GSH level in rats. Also, the results clearly showed that lead causes alterations of hepatic\udtissue in comparison with controls. Our results showed that treatment with A. malaccensis\udand A. longa a partial correction of the previous parameters. The histological observations\udconfirmed the hepatoprotection results by the biochemical parameters. Conclusions: Results\uddemonstrated beneficial effects of A. longa and A. malaccensis treatment in Pb-induced\udoxidative stress and tissue damage in liver