Open AccessEarly detection of anthracycline-induced cardiotoxicity in long-term survivors of acute lymphoblastic leukemia treated with low cumulative dose
Author(s) -
Giovanni Di Salvo,
Fabio D’Aiello,
Fortuna Del Gaizo,
Paolo Indolfi,
Fiorina Casale,
Maria Teresa Di Tullio,
D Iarussi,
Raffaele Calabrò,
Maria Giovanna Russo
Publication year - 2014
Publication title -
journal of cardiovascular echography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.255
H-Index - 8
eISSN - 2347-193X
pISSN - 2211-4122
DOI - 10.4103/2211-4122.132282
Subject(s) - medicine , parasternal line , cardiotoxicity , anthracycline , subclinical infection , cardiology , cumulative dose , lymphoblastic leukemia , diastole , strain rate imaging , diastolic function , nuclear medicine , leukemia , chemotherapy , cancer , blood pressure , breast cancer , strain rate , materials science , metallurgy
We investigated the left ventricular (LV) function, using for the first time strain (S) and strain rate (SR) imaging, in long-term survivors affected by acute lymphoblastic leukemia treated with a low cumulative dose of anthracyclines, and in presence of a normal global LV systolic and diastolic function. A total of 21 were enrolled in the study. The mean cumulative dose of anthracylines was 180 mg/m 2 (range: 120-210 mg/m 2 ). As control group 21 age-sex matched healthy subjects were included. Radial S (17 ± 3% vs. 55 ± 6%, P < 0.0001) and SR (2.1 ± 0.3 vs. 3.0 ± 0.8 1\s, P < 0.0001), assessed on the midsegment of the posterior wall from the parasternal views were significantly reduced when compared with controls. Conversely, myocardial performance index was not able to discriminate between patients and controls. In this preliminary study, the myocardial deformation indices appear to be a more sensitive noninvasive technique for detecting subclinical LV dysfunction than other echocardiographic measurements.