Open AccessCorrelation between spectral-domain optical coherence tomography parameters and neurological functional disability in multiple sclerosis
Author(s) -
Dalia H Khalil,
Dalia M. Labib
Publication year - 2015
Publication title -
journal of egyptian ophthalmological society
Language(s) - English
Resource type - Journals
eISSN - 2314-6648
pISSN - 2090-0686
DOI - 10.4103/2090-0686.174686
Subject(s) - medicine , optic neuritis , multiple sclerosis , optical coherence tomography , ophthalmology , retinal , nerve fiber layer , visual acuity , subclinical infection , expanded disability status scale , cohort , ganglion , visual field , clinically isolated syndrome , optic nerve , neurological examination , pathology , surgery , anatomy , psychiatry
PurposeThe aim of the present study was to correlate optical coherence tomography (OCT) parameters, including peripapillary retinal nerve fibre layer (RNFL) thickness and ganglion cell complex (GCC), retinal sensitivity (mean deviation and pattern SD of perimetry) and best-corrected visual acuity, with disease duration and neurological functional disability in multiple sclerosis (MS) patients with a history of optic neuritis (MS-ON) and without history of optic neuritis (MS-NON).Patients and methodsThe present cross-sectional, observational cohort study included 68 patients with MS and 23 age-matched and sex-matched healthy controls. All patients and controls underwent ophthalmic examination including visual acuity, visual field examination, OCT and neurological assessment.ResultsRNFL thickness was found to be decreased in MS eyes (89.35 μm) compared with controls (117.79 μm) (P < 0.000). MS eyes had decreased GCC (85.58 μm) compared with controls (96.16 μm) (P < 0.048). MS-ON eyes had decreased RNFL thickness (84.05 μm) compared with patients with MS-NON (92.41 μm) (P < 0.047). RNFL thickness was significantly negatively correlated to functional disability (Expanded Disability Status Scale) (P < 0.042) and disease duration (P < 0.000). GCC was significantly negatively correlated to disease duration (P < 0.008).ConclusionRNFL and GCC are significantly decreased in MS. OCT is a promising tool to detect subclinical changes in RNFL and GCC in patients with MS, and should be examined in longitudinal studies as a potential biomarker of retinal pathology in MS