Open AccessCorneal endothelial changes in type 2 diabetes mellitus before and after cataract surgery
Author(s) -
Hossam T Al-Sharkawy
Publication year - 2015
Publication title -
journal of egyptian ophthalmological society
Language(s) - English
Resource type - Journals
eISSN - 2314-6648
pISSN - 2090-0686
DOI - 10.4103/2090-0686.161400
Subject(s) - phacoemulsification , medicine , ophthalmology , intraocular lens , corneal endothelium , coefficient of variation , cataract surgery , diabetes mellitus , mann–whitney u test , endothelium , surgery , cornea , visual acuity , endocrinology , statistics , mathematics
PurposeThe aim of the study was to investigate the differences in corneal endothelium between patients with and those without diabetes before and after phacoemulsification with intraocular lens implantation.DesignThe study was designed as an interventional prospective comparative investigation.SettingThe study was conducted at Mansoura Ophthalmic Centre, Faculty of Medicine, Mansoura University, Egypt.Patients and methodsA total of 100 eyes of 99 patients (49 with and 50 without type 2 diabetes) with senile cataract underwent phacoemulsification with foldable intraocular lens implantation. Specular microscopy was performed preoperatively, at 1 week, and at 3 months postoperatively to evaluate endothelial cell density (ECD), endothelial cell size variability [coefficient of variation (CV)], and central corneal thickness (CCT). Data were analyzed using the t-test, the Mann-Whitney U-test, and Pearson′s correlation coefficient.ResultsPreoperatively, the mean ECD was 2558.20 cells/mm 2 , the mean CV was 39.84%, and the mean CCT was 512.56 μm in diabetic patients. In controls, the mean ECD was 2484.31 cells/mm 2 , mean CV was 41.03%, and mean CCT was 507.20 μm. There were no significant differences between the two groups (P = 0.145, 0.338, and 0.450 respectively). At 3 months postoperatively, the mean endothelial cell loss (ECL) was 8.09%, mean CV increase was 2.38%, and mean CCT increase was 3.00 μm in diabetic patients, whereas in controls the mean ECL was 8.36%, mean CV increase was 1.06%, and mean CCT increase was 1.30 μm. No significant difference was found in ECL between the two groups (P = 0.850), whereas the increases in CV and CCT were significantly more in diabetic patients than in controls (P = 0.001 and 0.031, respectively).ConclusionThere was no significant difference in the corneal endothelium preoperatively between diabetic and nondiabetic patients. Although no significant difference was found in ECL following phacoemulsification between the two groups, diabetic patients had a significantly greater increase in CV (polymegathism) and CCT compared with nondiabetic patients