Open AccessHigh flow nasal cannula as a method for rapid weaning from nasal continuous positive airway pressure
Author(s) -
Zohreh Badiee,
Alireza Eshghi,
Majid Mohammadizadeh
Publication year - 2015
Publication title -
international journal of preventive medicine/international journal of preventive medicine.
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.539
H-Index - 39
eISSN - 2008-8213
pISSN - 2008-7802
DOI - 10.4103/2008-7802.154922
Subject(s) - medicine , nasal cannula , continuous positive airway pressure , anesthesia , gestational age , weaning , respiratory rate , cannula , surgery , heart rate , blood pressure , pregnancy , biology , obstructive sleep apnea , genetics
Background: To compare two methods of weaning premature infants from nasal continuous positive airway pressure (NCPAP). Methods: Between March and November 2012, 88 preterm infants who were stable on NCPAP of 5 cmH 2 O with FIO 2 <30% for a minimum of 6 h were randomly allocated to one of two groups. The high flow nasal cannula (HFNC) group received HFNC with flow of 2 L/min and FIO 2 = 0.3 and then stepwise reduction of FIO 2 and then flow. The non-HFNC group was maintained on NCPAP of 5 cmH 2 O and gradual reduction of oxygen until they were on FIO 2 = 0.21 for 6 h, and we had weaned them directly from NCPAP (with pressure of 5 cmH 2 O) to room air. Results: No significant differences were found between 2 study groups with regards to gestational age, birth weight, Apgar score at 1 and 5 min after birth, patent ductus arteriosus and use of xanthines. The mean duration of oxygen therapy after randomization was significantly lower in HFNC group compared to non-HFNC group (20.6 ± 16.8 h vs. 49.6 ± 25.3 h, P < 0.001). Also, the mean length of hospital stay was significantly lower in HFNC group compared to non-HFNC group (11.3 ± 7.8 days vs. 14.8 ± 8.6 days, P = 0.04). The rate of successful weaning was not statistically different between two groups.Conclusions: Weaning from NCPAP to HFNC could decrease the duration of oxygen therapy and length of hospitalization in preterm infants