Open AccessEffects of probiotic supplementation on pancreatic β-cell function and c-reactive protein in women with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial
Author(s) -
Tanaz Shoaei,
Motahar HeidariBeni,
Hatav Ghasemi Tehrani,
Awat Feizi,
Ahmad Esmaillzadeh,
Gholamreza Askari
Publication year - 2015
Publication title -
international journal of preventive medicine/international journal of preventive medicine.
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.539
H-Index - 39
eISSN - 2008-8213
pISSN - 2008-7802
DOI - 10.4103/2008-7802.153866
Subject(s) - polycystic ovary , medicine , placebo , probiotic , gastroenterology , insulin , fasting blood sugar , randomized controlled trial , insulin resistance , endocrinology , diabetes mellitus , biology , alternative medicine , pathology , bacteria , genetics
Background: Polycystic ovary syndrome (PCOS) is a polygenic endocrine disorder in women of reproductive age that lead to infertility. The aim of this study was to investigate the effects of probiotic on pancreatic b-cell function and C-reactive protein (CRP) in PCOS patients. Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 72 women aged 15-40 years old diagnosed with PCOS. Participants were randomly assigned to two groups receiving: (1) Probiotic supplements (n = 36), (2) placebo (n = 36) for 8-week. Fasting blood samples were taken at baseline and after 8-week of intervention. Results: Probiotic supplementation, compare with placebo, reduced fasting blood sugar (−4.15 ± 2.87 vs. 2.57 ± 5.66 mg/dL, respectively P = 0.7), serum insulin levels in crude model (−0.49 ± 0.67 vs. 0.34 ± 0.82 mIU/mL, respectively, P = 0.09), homeostasis model of assessment-insulin resistance score (−0.25 ± 0.18 vs. −0.05 ± 0.18, respectively, P = 0.14) nonsignificantly. Serum insulin levels after adjustment with covariates reduced significantly in probiotic group (P = 0.02). We did not found any significant differences in mean changes of CRP between groups (−0.25 ± 0.18 vs. −0.05 ± 0.18, respectively, P = 0.14).Conclusions: A 8-week multispecies probiotics supplementation had nonsignificantly beneficial effect on pancreatic b-cell function and CRP in PCOS patients. After adjustment for some covariates, serum insulin changes were significantly different between groups