Open AccessWidespread Intracranial Calcification, Seizures and Extrapyramidal Manifestations in a Case of Hypoparathyroidism
Author(s) -
Imran Rizvi,
Noor Alam Ansari,
M. Salim Beg,
Dilawez Shamim
Publication year - 2012
Publication title -
north american journal of medical sciences
Language(s) - English
Resource type - Journals
eISSN - 2250-1541
pISSN - 1947-2714
DOI - 10.4103/1947-2714.99523
Subject(s) - hypoparathyroidism , medicine , extrapyramidal symptoms , calcification , basal ganglia disease , basal ganglia , pseudohypoparathyroidism , hyperphosphatemia , pathological , differential diagnosis , pathology , schizophrenia (object oriented programming) , central nervous system , calcium , psychiatry , parathyroid hormone , antipsychotic
Hypoparathyroidism can present with neurological complaints like seizures, parasthesias, depression, psychosis, extrapyramidal manifestations and features of raised intracranial pressure. Hypoparathyroidism and pseudohypoparathyroidism are the most common causes of pathological basal ganglia calcification. A 50 year male presented with generalized seizures and extrapyramidal features like tremors and rigidity. Investigations revealed that he had hypocalcemia, hyperphosphatemia and very low PTH levels, CT scan of head showed calcification of bilateral basal ganglia, cerebellum and subcortical white matter of frontal and parietal lobes. He showed remarkable recovery on restoration of normal serum calcium levels. Hypoparathyroidism should be kept in the differential diagnosis of patients presenting with seizures and extrapyramidal features.