Open AccessA randomized double-blind placebo-controlled study to compare preemptive analgesic efficacy of novel antiepileptic agent lamotrigine in patients undergoing major surgeries
Author(s) -
Priyank Shah,
Uma A Bhosale,
Ankush Gupta,
Radha Yegnanarayan,
Shalini Sardesai
Publication year - 2016
Publication title -
north american journal of medical sciences
Language(s) - English
Resource type - Journals
eISSN - 2250-1541
pISSN - 1947-2714
DOI - 10.4103/1947-2714.177315
Subject(s) - medicine , analgesic , gabapentin , anesthesia , lamotrigine , placebo , pregabalin , visual analogue scale , neuropathic pain , randomized controlled trial , clinical trial , surgery , epilepsy , alternative medicine , pathology , psychiatry
If postoperative acute pain remains unrelieved, it may result in significant morbidity and mortality. Preemptive analgesic initiated before surgery offers premature analgesia even before exposure to an initial noxious stimulus bestowing effective postoperative analgesia. In developed countries, it is regularly practiced as a part of well-defined protocol. In our country however, only a few centers practice it and that too irregularly and with undefined protocol. Few studies support preemptive analgesic efficacy of novel antiepileptic agent gabapentin. Though lamotrigine is a proven analgesic in animal models of chronic pain and clinical studies of gabapentin-resistant neuropathic pain, a literature search revealed scarce data on its preemptive analgesic efficacy.