Open AccessComparative study of positive versus negative autologous serum skin test in chronic spontaneous urticaria and its treatment outcome
Author(s) -
Y Hari Kishan Kumar,
Sapnashree Bhaskar,
K C Madhu Shankar
Publication year - 2016
Publication title -
north american journal of medical sciences
Language(s) - English
Resource type - Journals
eISSN - 2250-1541
pISSN - 1947-2714
DOI - 10.4103/1947-2714.175195
Subject(s) - medicine , immunoglobulin e , population , basophil , itching , dermatology , gastroenterology , immunology , antibody , environmental health
Chronic urticaria (CU) is defined as urticaria persisting daily or almost daily for more than 6 weeks and affecting 0.1% of the population. Mast cell degranulation and histamine release are of central importance in the pathogenesis of CU. About 40-50% of the patients with chronic idiopathic urticaria (CIU) or chronic spontaneous urticaria (CSU) demonstrates an immediate wheal and flare response to intradermal injected autologous serum. This led to the concept of autoimmune urticaria (AIU).