Open AccessMetabolic signatures of oxidative stress and their relationship with erythrocyte membrane surface roughness among workers of manual materials handling (MMH)
Author(s) -
Subrata Bandhu Ghosh,
Muktish Acharyya,
Titlee Majumder,
Anandi Bagchi
Publication year - 2015
Publication title -
north american journal of medical sciences
Language(s) - English
Resource type - Journals
eISSN - 2250-1541
pISSN - 1947-2714
DOI - 10.4103/1947-2714.172846
Subject(s) - oxidative stress , malondialdehyde , surface roughness , glutathione , medicine , population , physiology , biophysics , pathology , biomedical engineering , biochemistry , chemistry , materials science , biology , composite material , environmental health , enzyme
Brickfield workers in India perform manual materials handling (MMH) and as a result, are at a high risk of developing oxidative stress. This results in an alteration of the various markers of metabolic oxidative stress at the cellular level. Since red blood cell (RBC) is the central point where oxygen, glucose-6-phosphate dehydrogenase (G-6-PD), and glutathione (GSH) are involved, the surface roughness and its alteration and modeling with respect to workers exposed to MMH may be considered as helpful determinants in predicting early damage to the cell and restoring better health to the exposed population, that is, the worker exposed to stress. Hence, nanometric analysis of the surface roughness of the RBC may serve as an early indicator of the stress-related damage in these individuals.